Thank god that brain tumor may be the death of Izzy yet! "Grey's Anatomy" cast member James Pickens Jr. says the medical drama will be saying goodbye to popular stars Katherine Heigl (Izzy) and T.R. Knight (George). Pickens (Dr. Webber), told Us Weekly magazine that he wishes Heigl "nothing but the best" in her budding big screen film career while Knight is leaving the fadding show to pursue other "career paths."

"Katherine is ready to move on to the next chapter," says another set source. And TR is "not shy" about telling everyone he wants out of his contract.

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