Patricia Arquette admits feeling a sense of "loss" when younger brother Alexis announced his plans to become a woman. The "Medium" star had questioned her open-mindedness when she doubted her brother's transgender plans.

The 39-year-old actress says, "I had all the questions [for him] at first: 'Do you love yourself? Is it something that you want to change about the way you look?' I get concerned when anybody I love wants to do any change to the way they look - where's this coming from and why?"

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