The vampires were only a hot item for about a week as Vince Vaughn and Reese Witherspoon's surprising hit comedy "Four Christmases" easily won the box office top spot with a take of $46.7 million in the 4-day holiday weekend run.

If that estimated amount hold, it would make the comedy the third-best Thanksgiving weekend opener ever, after Toy Story 2 ($80M) and last year's Enchanted ($49M). It's also a best for Vaughn since 'The Break-Up', and it's Witherspoon's best since 'Sweet Home Alabama' more than six years back.

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