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Her partner Julie Cypher gave birth to two children, Bailey Jean (born in 1997) and Beckett (born in November 1998), which were adopted by Melissa. Close friends with Brad Pitt. Announced she is separating from long-time partner Julie Cypher (19 September 2000). Ranked #49 on VH1's 100 Greatest Women of Rock N Roll Sang at Brad Pitt's and Jennifer Aniston's wedding Was diagnosed with breast cancer (October 2004). Announced in late 2005 that she is cancer-free and that she and partner Tammy Lynn Michaels are planning to have a child. Her partner Tammy Lynn Michaels gave birth to a girl, Johnnie Rose, and a boy, Miller Steven, on 17 October 2006. Her father John died from cancer in 1992. Won two Grammy Awards for "Best Female Rock Performance" in 1992 and 1994.