As a child, he produced a number of short films on Super 8 and video before beginning his studies as a film director in Munich and Vienna. He also studied literature and economics in Cologne and Siegen. Uwe graduated from university in 1995 with a doctorate in literature. From 1995-2000, he was a producer and director with Taunus Film-Produktions GmbH. Boll is currently Chief Executive Officer of Boll Filmproduction and Distribution GmbH which he founded in 1992. In 2000 he founded Boll KG and continues to direct, write and produce feature films.
All three of the films he's directed that were based upon video games, House of the Dead, Alone in the Dark, and BloodRayne are listed on the IMDb Bottom 100. The other seven films he's directed, including Heart of America, Blackwoods and Erste Semester, Das are not widely available in America, but have received similarly low ratings among those who have seen them. His favorite video-game is Hitman: Codename 47. His favorite film of 2005 is Sin City. He is good friends with Clint Howard and cast him in Blackwoods, Heart of America and House of the Dead. Challenged his critics in June 2006 to "put up or shut up". His production company issued a press release stating that Boll would challenge his 5 harshest critics each to a 10 round boxing match. To be eligible, the critic must have written two extremely negative reviews of Boll, in print or on the Web, in 2005. Footage of the fights will be included in his upcoming film Postal.