Sprague Grayden has been acting since the age of five. After graduating cum laude from Barnard College, Grayden worked as a performing member of the Drama Department in New York City. Her additional theater credits include Hopscotch, The Vagina Monologues, Fool for Love, Hamlet, Waiting for Lefty and Ordinary Day. Her television credits include a recurring role on HBO's Six Feet Under, a starring role on Fox Televisions's John Doe, and a guest appearance on Law & Order: Special Victims Unit. Her feature film credits include Dad starring Jack Lemmon.
Her first name is her mother's maiden name.