At 16 Sherrie Rose left the trailer park she grew up in and attended USF as an engineering student. She was on the Dean's List for electrical engineering and theatrical performance at the same time. She became an actor after installing the sound board in the theater at the University and saw how much fun and camaraderie the actors had on the stage. She got great reviews from her first play, and got parts in Miami Vice and a lead in the comedy Summer Job. She was entered for an Emmy nomination for her work in Tales from the Crypt.

She shares the same birthday as Billy Zane, who acted with her in Demon Knight, and they often celebrate together. Rose wrote, directed, produced and starred in her own movie, Me and Will, that opened the "Women in Film" series on the Sundance Channel, and her friend Keanu Reeves did a cameo.

She was engaged to Michael DeLuise, and dated Ray Liotta after being in Unlawful Entry together and more recent boyfriends were rocker David M. Navarro and young Shane West.