Megan is an only child born in Los Angeles, California. Her mother, Martha, was a model. Her father, Carter Mullally Jr., is a retired contract player for Paramount. Megan first entered Northwestern University intending to study acting, but switched to English literature. However, she still ended up starring in several campus musicals, which gained attention from producers and prompted her to drop out of school. In 1985, she moved to Los Angeles with no particular success. But, in 1994, she co-starred in "Grease" with Rosie O'Donnell and, in 1995, in "How To Succeed In Business" with Matthew Broderick. Her star has been rising ever since.



Lives in West Hollywood, California with her poodles, Willa and Elmo. She recently starred in and directed an original performance art piece, The Sweetheart Break-In. The band released a CD of some of the songs in the show, called 'The Supreme Music Program: The Sweetheart Break-In'. Her father, Carter Mullally Jr., who died in the late '90s, was a contract player with Paramount in the 1950s. Her mother, Martha, was a former model. Close friend is "ER" (1994) actress Laura Innes. The two met at Northwestern University in the late 70s and have been friends ever since. Auditioned for the role of Elaine on "Seinfeld" (1990). (According to the Seinfeld special, aired on 25 November 2004.) Has won 3 consecutive Screen Actors Guild Awards (SAG) for Outstanding performance by an actress in a comedy, and has a total of 4 SAG Awards and 2 Emmy Awards. Originally auditioned for "Grace" on "Will & Grace" (1998), but was later cast as "Karen". She almost wound up in the role of Carrie in "The King of Queens" (1998). Irish-American. Has with drawn from the Broadway production of Lips Together, Teeth Apart. Due to creative differences with the director Joe Mantello.