Ellen Pompeo made her major studio screen debut in Brad Silberling's Moonlight Mile, starring alongside Susan Sarandon, Dustin Hoffman and Jake Gyllenhaal. She received outstanding reviews for her portrayal of an outspoken young woman carrying a silent burden that's breaking her heart.

A native of Boston, Pompeo starred opposite Luke Wilson, Vince Vaughn and Will Ferrell in the wildly successful Old School and, before that, in Steven Spielberg's Catch Me If You Can, opposite Leonardo DiCaprio.

Prior to Moonlight Mile, Pompeo starred in several independent features, including In the Weeds and Coming Soon, and she can also be seen in Life of the Party.
Is a native of Boston. Had another scene in Daredevil as Matt Murdock's (Ben Affleck) secretary Karen Page, but it was deleted from the theatrical version of the film. Before Grey's Anatomy, she auditioned for a television pilot called "Secret Service". That show was not picked up by any television network. She is the youngest of 6 - she has 5 siblings who are all at least 8 years older than her. One of them is Maureen Pompeo. Suffers from asthma. Her mother died when she was only 4 years old. Her father is Joseph Pompeo, a salesman. Engaged to music producer Chris Ivery [November 13, 2006]. After they started dating three years ago, they learned that they both grew up in Boston, 10 miles from each other. Had a part in Eternal Sunshine of the Spotless Mind, which was deleted from the final cut. She's engaged to music producer Christopher Ivery. Was approached to play the role of Becky in Clerks II, but turned it down because she had just finished the pilot for Grey's Anatomy. Wed fiancé Christopher Ivery in a civil ceremony in New York City on November 9, 2007. The only people in attendance were Mayor Michael Bloomberg and First Deputy Mayor Patti Harris, who served as witnesses to the ceremony.