Brooke Smith grew up in New York in the shadow of show business due to the fact that she is the daughter of powerful publicist Lois Smith. After studying at the American Academy of Dramatic Arts her "first big thing" was playing Catherine Martin, the abducted young girl in The Silence of the Lambs. She went on to play Sonya in Louis Malle's Vanya on 42nd Street and Dawn in Daniel Minahan's brutal send up of reality television Series 7: The Contenders. Whether she is humming a Tom Petty tune, like her character did in "Lambs" or screaming for a bean dip, like her pregnant character does in "Series 7," Smith is known for giving brooding, detailed performances. In addition to stage work, her other interests include: filmmaking, she has directed a short film and a feature length documentary, journalism, she has had published interviews with actors Steve Buscemi, Ed Harris and Fred Ward and she has traveled extensively, especially to Africa.
She attended Tappan Zee High school Gained 25 pounds for her role as "roomy" Catharine Martin in The Silence of the Lambs. Shared an apartment with Jeff Buckley before the recording of his album, Grace.