Graduated from Yale University. Wanted to be an actor, but parents initially weren't supportive. This changed when in college he sang in Leonard Bernstein's Mass, and Bernstein himself saw Picardo and told him he should pursue being an actor. The young Picardo asked Bernstein to tell that to his parents, which the great composer did, thereby changing their minds. Picardo started as a noted stage actor, appearing in Gemini on Broadway, among others.
From the East Falls section of Philadelphia Graduate of Penn Charter School, class of 1971 Originally attended Yale as a Pre-Med major Is an acomplished singer and has put out a CD of parody songs. Is the only "Star Trek" regular to have ever written an episode of "Star Trek": the Star Trek: Voyager Season Six episode "Life Line". Had originally auditioned for the role of Neelix on Star Trek: Voyager. Along with George Takei and Robert Duncan McNeill, he is one of only three "Star Trek" regulars to wear all three "Star Trek" uniform colours. He wore the blue (medical) uniform in every episode of Star Trek: Voyager in which he appears, the Star Trek: Deep Space Nine episode "Doctor Bashir, I Presume?" and Star Trek: First Contact, the gold (operations/security) uniform in the Star Trek: Voyager episode 'The Swarm' and the Star Trek: Deep Space Nine episode 'Doctor Bashir, I Presume?' and the red (command) uniform in the Star Trek: Voyager episode 'Tinker, Tenor, Doctor, Spy'. Has appeared in episodes of two different series entitled "Prototype": Star Trek: Voyager and Stargate SG-1. Has appeared in episodes of two different series entitled "The Gift" and "One Small Step": China Beach and Star Trek: Voyager. Is a fan of Stargate SG-1 on which he plays the recurring character of Agent Richard Woolsey. Has two daughters named: Nicollette Arianna (born on March 14, 1989) and Gina Emira (born on November 3, 1991)