Born in Hollywood, CA, as one of six children of an electrical engineer and an orthopedic head nurse. Participated in a theater arts program at Northwestern University during high school and appeared in high school plays. After graduation he learned from acting teacher Larry Moss while living in a small apartment on Hollywood Boulevard. His first parts were a mini-series and featuring in the movie Crooked Hearts in 1990.


Went on stage and gave a speech at MacWorld computer trade show posing as Apple Computer interim chief Steve Jobs. Jobs invited Wyle for this joke after seeing him in Pirates of Silicon Valley (1999) (TV). [July 1999] Announced his engagement to makeup artist Tracy Warbin [March 1999] Collects baseball cards, antiques and any bric-a-brac pertaining to the Biblical Noah's Ark. Educated at Thacher School (Ojai, California) and Northwestern University November 9, 2002: his wife Tracy Warbin gave birth to son Owen Strausser Wyle in a Los Angeles area hospital. September 2004: Announced that he's leaving "ER" (1994) after 10 years to make room for the upcoming generation. His wife, Tracy Warbin, gave birth to a girl, Auden Wyle, in Los Angeles, weighing in at 7lb. 7oz. on October 15, 2005. Seperated from wife Tracy Warbin in late October 2009.