A native of Chicago, Weiss began acting as a child, appearing in local TV commercials. While in high school, he studied acting at the Second City workshop, and after graduation, he enrolled in USC's prestigious school of drama. Shortly after receiving his B.F.A. there in 1984, Weiss landed the role of Dr. Mike Horton on NBC's venerable daytime drama "Days of Our Lives."

His dad is a steel-industry executive & his mom is a homemaker. He worked as a personal trainer, with many of his clients being fellow actors. He attended the University of Southern California where he joined the school of drama. Says his home is chemical free. He uses only minimum elctricity and drives a Toyota Prius, an electric-gas hybrid vehicle. He can accurately name each of the United States in alphabetical order (without a break to stop and think about it), He can change his voice pattern to reflect certain accents or dialects He can wiggle his ears Is a certified scuba diver Younger brother of make-up artist Jamie Sue Weiss. Michael was an usher at former Cruise of Deception: Days of Our Lives co-star Lisa Howard's 1985 wedding to husband Daniel Cerone. Appeared more recently on Boston's Huntington Theatre stage in "Burn This" (2004) and "Les Liaisons Dangereuses" (2006).