John Mayer says he has a supply of anti-anxiety drug Xanax with him at all times to combat any downward spirals. "There are these incidental kinds of loopholes in my brain, where the wires can cross for a second and the hard drive crashes," he tells Best Life, adding that his first "anxiety bender" occurred when he was in his 20s. "You can create dark neighborhoods in your mind as easily as you can create rural wonderlands."

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