Joe Piscopo was cast on SNL 25 in 1980 as part of an overall replacement of the original cast. However, his team of players were not up to par in comedy and were all replaced themselves, except for he and Eddie Murphy. Together they dominated the show for the next three years. Since then his opportunities have been less frequent. In the '90s he was treated for thyroid cancer.

He's the guy in the trench coat in Billy Joel's "Keepin' The Faith" music video. He sat out of show business briefly while he underwent treatment for thyroid cancer. He has three children - Joey Piscopo, born in 1979, Alexandra, Michael, and Olivia. Graduated from Jones College in Jacksonville, Florida. He worked with Eddie Murphy on Saturday Night Live, they became very good friends, Murphy even bought a home in his neighbourhood in 1982. They produced a short film for SNL about his street behaviour fitting in with the New Jersey suburbs. His wife Kimberly gave birth to their third child, daughter Olivia, on 29 November 2004. Known for outrageous Miller Lite commercials in the 1980s.