Jason Isaacs is the 3rd of 4 children.

He studied Law at Bristol University and graduated in 1985 with a degree in law but decided to study acting.

Whilst at Bristol University he directed and/or appeared in over 20 productions.

Whilst at the Central School of Speech and Drama he met his wife Emma and graduated from there in 1989.
Has a daughter named Lily, born on 23 March 2002 Was set to play Dr. William Birkin in Resident Evil: Apocalypse, but left the project. Had an uncredited role as Dr. William Birkin (and the narrator) in Resident Evil. Has a daughter named Ruby, born August 2005. Shares two roles with Hans Conreid. Conreid appeared in the Walt Disney animated version, while Isaacs appeared in the 2003 live action film. Both films followed a tradition encouraged by James Barrie, and followed in most stage productions, that Mr. Darling and Captain Hook be played by the same actor. Accordingly, he and Conreid played both parts in their respective films. Longtime best friend of writer/director Paul W.S. Anderson.