Horatio Sanz was born on June 4, 1969, in Santiago, Chile, and raised in Chicago, Illinois. He was one of the Upright Citizen Brigade's founding members and performed with Chicago's Second City comedy troupe.

When he joined the cast of SNL 25 as a featured player at the beginning of the 24th season (September 26, 1998), he became the long-running sketch comedy show's first Latino cast member. He appeared along with fellow featured players Jimmy Fallon and Chris Parnell, and after only one season, the three were promoted to cast members. On the show, Horatio played the characters Frankie Hilbert on the sketch "Boston Teens", pothead Gobi on the recurring sketch "Jarret's Room", and A/V teacher Mr. Banglian on "Wake Up, Wakefield."

Horatio has had many minor but memorable roles in movies since 1994. However, his big break came in 2003 with his first starring role in the movie Boat Trip, in which he appeared along with Cuba Gooding Jr. and Vivica A. Fox. He continues to star on SNL 25.
Enjoys rap music and sleeping late. Was a member of of the Second City comedy troup Saturday Night Live's first Latino Castmember Is notorious for making "Saturday Night Live" castmate Jimmy Fallon laugh on-screen in several sketches. Recent impressions on Saturday Night Live include Sadaam Hussain, Elton John and Ozzy Osbourne. One of the original and founding members of the Upright Citizens Brigade improv troupe. When the troupe decided to move from Chicago to New York City, Horatio stayed in Chicago, while the rest of the group created their own show for Comedy Central in NYC which Horatio wasn't a part of but would make occasional cameos. Had a small role in Spider-Man as the fan who yells "Cage!" during the wrestling match. Later he would play Spider-Man (sort of) during Kirsten Dunst's opening monologue when she hosted the show. Is a Chicago Bears fan.