James Gregory Vaughan, Jr., was born in Dallas, Texas, on June 15, 1973, and was raised in both the big city of Dallas and the small German town of Fredericksburg, Texas, from his preschool years through his early teens, graduating from Mesquite High in 1991. Vaughan was involved in sports, student government, and a few school talent productions. At 16, before graduating high school, he was discovered in a community back-to-school fashion show, and was immediately signed up by a local modeling agent.

With the opportunity to travel the world, he bypassed college and ventured to Milan, Italy, just months after high school graduation. Upon his arrival, he landed prestigious campaigns for the legendary designers Giorgio Armani and Gianni Versace, further ensuring his newfound success by adding Banana Republic, Tommy Hilfiger, and Ralph Lauren all before the age of 21.

Relocating from city to city, a life requiring only a suitcase, came to an end through his mother's influence. She encouraged him to follow his true passion: acting. Vaughan's acting career began with abundant commercial work, preparing him for what he now claims has become his life's work over the past 10 years.

In 1996, Vaughan made his television series debut as Josh Walker in the popular Aaron Spelling series Malibu Shores, which soon spun off into Beverly Hills 90210, where Vaughan played Cliff Yeager (1996-1997). Trying his hand at a few small independent films, he was cast in the popular cult films Poison Ivy and The New Seduction (1997), followed by No Small Ways (1998), which led him back home to Austin, Texas. Upon returning to Los Angeles, he began filming Children of the Corn, Field of Terror (1998).

Vaughan spent his time between projects in a number of guest-starring television appearances in series that included Buffy the Vampire Slayer, Any Day Now, Sabrina the Teenage Witch and Nash Bridges before shooting a controversial "dramody" pilot, Student Affairs, for Imagine Television.

Spelling Entertainment soon created a role for Vaughan as a series regular, boy-next-door Dan Gordon, on Charmed (1999-2000). After the series ended, Vaughan quickly landed the role of Milo Mosley in Glory Days, the highly anticipated Kevin Williamson series. After its short television run, Vaughan began his foray into daytime drama as Diego on CBS's #1 The Young & The Restless. With rave reviews and notoriety, a Daytime Best Newcomer nomination followed, with People Magazine naming Greg Vaughan as "One of the Sexiest Men Alive" in 2002. Finding little spare time, he still managed to appear in guest roles on both Will & Grace and Still Standing before jumping from one daytime drama to another. Vaughan's opportunity to grab the highly acclaimed role of Lucky Spencer on General Hospital seems to have simply happened before anyone knew it.
Briefly dated co-star Alyssa Milano. Is also a model Greg is engaged to Touriya Haoud.