Greg Kinnear was born on June 17, 1963, in Logansport, Indiana, USA to parents Edward Kinnear, a career diplomat who worked for the US State Department and Suzanne Kinnear, a full-time homemaker. Greg also has two brothers--one named James, Vice President-Investments at Wachovia Securities in Arizona (born in 1957), and one named Steve, a business manager who works for the Billy Graham Training Center in North Carolina (born in 1959). As a child, Greg and his family moved around a lot, from places as far as Beirut, Lebanon to Athens, Greece. While a student in Athens, Greg first ventured into the role of talk show host with his radio show "School Daze With Greg Kinnear."

Returning to the States for a college education, he attended the University of Arizona in Tucson, where he graduated in 1985 with a degree in broadcast journalism. From Arizona he headed out to Los Angeles, where he landed his first job as a marketing assistant with Empire Entertainment. Following this job he auditioned to be an MTV VJ, but failed and became a host and on-location reporter for the channel. When that job went under he had bit parts on such television shows as L.A. Law and Life Goes On. He would later become the creator, co-executive producer, and host of Best of the Worst, which aired from 1990 to 1991. He then received his breakthrough when he became the first host of Talk Soup until 1994, when he left the show for the NBC late-night talk show, Later with Cynthia Garrett. It was also in 1994 that Kinnear had his first big screen role, as a talk show host yet again in the Damon Wayans comedy Blankman. In 1995 he won the part of the David Larrabee in Sydney Pollack's remake of Billy Wilder's 1954 classic Sabrina. He then received the lead role in the 1996 comedy Dear God. In 1997, Greg was cast in James L. Brooks's blockbuster comedy drama As Good as It Gets, for which he received an Oscar nomination for Best Supporting Actor. His next film, the romantic comedy A Smile Like Yours, had him starring opposite Lauren Holly as part of a couple trying to have a baby. The film met with lukewarm reviews and a low box office, but his next film, You've Got Mail, struck gold. He played Meg Ryan's significant other, a newspaper columnist wholly unlike what was to be his next character, that of Captain Amazing in the 1999 summer action film Mystery Men. His more recent films have Nurse Betty, The Loser, and Someone Like You....
Attended the University of Arizona, where he graduated in Broadcast Journalism (1985) Lived in Greece for a time and can speak Greek. Member of Alpha Tau Omega fraternity. He and his wife Helen's baby was stillborn in 2001. Daughter, Lily Katherine born in September 2003. Greg and Helen became the parents of a second girl, Audrey Mae, on June 13, 2006.