Giuseppe Andrews was born in Key Largo, Florida. His real name is Joey Andrews, but later grew up and thought his name sounded too young and was changed to Giuseppe after the Italian composer, Giuseppe Verdi. After his parents divorced, Andrews became interested in acting as a child. He moved to Los Angeles for his father's work and at that time, he lived in a van. He read an ad in the magazine for auditions of an agency and decided to go for it. He was signed up and he says that it was really hard to get into the industry, but he was very lucky.

Since that, he has been in many films, television movies and programs, and music videos. He is best known as his role for Lex in Detroit Rock Cityand his role as Germ on the television show Two Guys, a Girl and a Pizza Place. He can also be seen in Smashing Pumpkin's '1979' music video and Smashing Pumpkin's 'Perfect' music video. His next goal is to be more involved behind a camera, like writing and directing his own films. He also writes music and he hopes to combine them into his future films, too.