Dylan McDermott and his wife of nearly 12 years, actress Shiva Rose, have separated, his rep confirms to PEOPLE.

McDermott, 45, and Rose, 38, have been married since 1995 and have two daughters, 11-year-old Collette and 2-year-old Charlotte.

Last night marked the premiere of McDermott's new show on ABC, Big Shots.  It's being touted as the male equivalent to Sex & The City.  Anyone catch it?
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